Beilstein J. Org. Chem.2023,19, 1408–1442, doi:10.3762/bjoc.19.102
carboxylation, C(sp2)–H alkenylation and allylation, C(sp2)–H arylation, C(sp2)–H amidation, and C(sp2)–H thiolation. Preceding the section of applications, a brief description of the structure of NHCs, nature of NHC–metal bond, and methods of preparation of NHC–Cucomplexes is provided.
Keywords: conjugate
addition; [3 + 2] cycloaddition reaction; hydrosilylation reaction; N-heterocyclic carbenes; NHC–Cucomplexes; NHC–Cucomplexes as catalyst; Introduction
N-Heterocyclic carbenes (NHCs) are a neutral species having the carbene carbon atom as a part of the nitrogen heterocyclic ring. The transient
employed for the preparation of numerous NHC–Cucomplexes, requires the use of strong bases and rigorous inert conditions. However, an alternative method called transmetallation method has also been employed for the preparation of NHC–Cu(I) complexes by using NHC transfer reagents. For this purpose, NHC–Ag
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Graphical Abstract
Scheme 1:
In situ generation of imidazolylidene carbene.